https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Sleeping giants: emerging roles for the Fat cadherins in health and disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19159 Sat 24 Mar 2018 07:52:20 AEDT ]]> FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19310 Sat 24 Mar 2018 07:52:15 AEDT ]]> FAT1 Gene Expression in Iranian Acute Lymphoid and Myeloid Leukemia Patients https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51247 0.2). Nonetheless, the mean expression level of FAT1 was significantly higher in leukemic patients (AML and ALL) than in normal CD34+ cells (p=0.029). Additionally, the FAT1 expression levels were significantly higher in both CD34+ and CD34-leukemic patients than in normal CD34+ cells (p=0.028). Conclusion: No significant differences were found between FAT1 expression in CD34+ and CD34-leukemic samples (p> 0.3). Thus, higher FAT1 expression was evident in ALL and AML leukemia cells but this appeared unrelated to CD34 expression. This suggests in a proportion of adult acute leukemia, FAT1 expression may prove to be a suitable target for therapeutic strategies.]]> Mon 28 Aug 2023 12:28:18 AEST ]]> Assembly and activation of the Hippo signalome by FAT1 tumor suppressor https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43403 Fri 16 Sep 2022 10:05:31 AEST ]]>